Atlas Antibodies Blog

Today we meet with Dr. Peter Thul, group leader at the Human Protein Atlas (HPA) project, Stockholm, Sweden. Peter is one of the scientists behind the Cell Atlas: a database that provides high-resolution insights into the expression and spatio-temporal distribution of proteins within human cells. We asked Peter 10 questions about the past, the present, and the future of the Cell Atlas.

The Annual Society for Neuroscience (SfN) meeting features the latest discoveries in brain research, from the basic mechanisms, to translational and clinical studies. Here are some highlights from the conference.

Attend our AAAS/Science-hosted webinar “The Brain Atlas: A road map through the complex protein signature of the brain” and learn more about the Brain Atlas, part of the Human Protein Atlas (HPA), from the scientists behind the project. Register today!

Today we meet with Dr. Jan Mulder, group leader of the Human Protein Atlas (HPA) brain profiling group at Karolinska Institutet, Stockholm, Sweden, and the director of the Brain Atlas, a brand-new addition to the (HPA) project. His research interest is to identify proteins involved in brain development, normal brain physiology and pathophysiology of brain disorders by using an antibody-based approach combined with multiplex fluorescence immunohistochemistry.

We asked Jan 10 questions about the past, the present, and the future of the Brain Atlas.

The Brain Atlas is a tool that brings the human brain mapping on a new level. It provides an overview of all the proteins expressed in the brains of three mammalian species: human, mouse and pig. It also compares the proteins in the brain to the proteins in other tissue types of the human body. Excited? Read more.

Applied biological or biomedical research aims to reach a thorough understanding of the physiology of organisms and to further development of disease therapeutics. Some scientific discoveries have narrow applicability or scope and are sometimes serendipitous or even entirely unexpected. Other have wider applicability and transferability having proved enormously useful over a wide range of domains. Among the latter are research antibodies. Read more to discover how they help progressing science.

Washing- and staining solutions, blocking agents, detection and mounting solutions. Successful immunohistochemical staining requires reliable, high-quality reagents to fixate, to wash and permeabilize the tissue. But what is the rationale behind the fact that certain buffers or storage conditions are better to use than other, or is it all just empiric?

Today we meet with Dr. Cecilia Lindskog, group leader at Uppsala University in Sweden, and the site director of the Tissue Atlas part of the Human Protein Atlas (HPA). Her research is focused on protein science, understanding the biology and functions of human proteins expressed in different organs, and the underlying mechanisms leading to cancer and other diseases. We asked her 10 questions about the past, the present, and the future of the Tissue Atlas.

We have run the exact same experiment. I found X. You found Y. Why? Have you been in this conversation with a collaborator? Have you ever obtained amazing results which contradict previous theory? Before you read on, take a moment to answer that for yourself. What was your reaction? “It is all my fault. I must have done something wrong” or “Interesting, I never thought about that before…” 

The human body is the results of trillion of cells communicating with each other. Early biologists described cells as simple membranous sacs containing fluid and a few floating particles. Today we know that cells are infinitely more complex than that. Read here about the Cell Atlas, part of the Human Protein Atlas, for insights into the spatio-temporal distribution of proteins within human cells.